Dichloromethane → 2-[3,5-bis(trifluoromethyl)phenyl]-N-{[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}acetamide

HRID 2128291Notes

Reaction equation

HRID 2128291 reaction equation
[CH3:78][CH2:79][O:80][C:81]([CH3:82])=[O:83].[CH:19]([N:20]([CH2:21][CH3:22])[CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[CH:52]([CH3:53])([CH3:54])[c:55]1[cH:56][cH:57][c:58]([O:73][CH3:74])[c:59](-[c:61]2[c:62]([CH2:71][NH2:72])[cH:63][c:64]([C:67]([F:68])([F:69])[F:70])[cH:65][cH:66]2)[cH:60]1.[Cl:75][CH2:76][Cl:77].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][C:14](=[O:15])[OH:16])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:17])[F:18].[P-:28]([F:29])([F:30])([F:31])([F:32])([F:33])[F:34].[n:35]1([O:36][C:37]([N:38]([CH3:39])[CH3:40])=[N+:41]([CH3:42])[CH3:43])[c:44]2[n:45][cH:46][cH:47][cH:48][c:49]2[n:50][n:51]1>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][C:14](=[O:15])[NH:72][CH2:71][c:62]2[c:61](-[c:59]3[c:58]([O:73][CH3:74])[cH:57][cH:56][c:55]([CH:52]([CH3:53])[CH3:54])[cH:60]3)[cH:66][cH:65][c:64]([C:67]([F:68])([F:69])[F:70])[cH:63]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:17])[F:18]

Participants

8

Reactant 7

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 1235873,5-Bis(trifluoromethyl)phenylacetic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 591351271-[5'-Isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methanamine

Product 1

HCID 866153972-[3,5-bis(trifluoromethyl)phenyl]-N-{[5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}acetamide

Sources & evidence

ORD record
ord-4cccef3a8656497086a20bbf20cecdb4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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