Triethylamine → Tert-butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate

HRID 213636

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]2[O:11][CH:12]2[CH2:13]1.[CH2:17]([N:18]([CH2:19][CH3:20])[CH2:21][CH3:22])[CH3:23].[FH:14].[FH:15].[FH:16]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([F:14])[CH:12]([OH:11])[CH2:13]1

Participants

Reactant 3

HCID 8471Triethylamine

HCID 14917Hydrofluoric Acid3×

HCID 10103880tert-Butyl 6-Oxa-3-azabicyclo(3.1.0)hexane-3-carboxylate

Product 1

HCID 53249784Tert-butyl 3-fluoro-4-hydroxypyrrolidine-1-carboxylate

Sources & evidence

ORD record: ord-92bb29fec607480999575b6feaa79e11
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Linked notes

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