Tetrahydrofuran → 2-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropionaldehyde

Reaction equation

[Al+3:24].[CH3:1][C:2]1=[C:3]([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[C:4](=[O:16])[N:5]([C:8]([C:9](=[O:10])[O:11][CH2:12][CH3:13])([CH3:14])[CH3:15])[CH2:6][O:7]1.[H-:23].[H-:26].[H-:27].[H-:28].[Li+:25].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[CH3:1][C:2]1=[C:3]([c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[C:4](=[O:16])[N:5]([C:8]([CH:9]=[O:10])([CH3:14])[CH3:15])[CH2:6][O:7]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 10968683Ethyl 2-methyl-2-(6-methyl-5-phenyl-2,3-dihydro-4-oxo-4H-1,3-oxazin-3-yl)-propionate

Product 1

HCID 221182842-(2,3-dihydro-6-methyl-4-oxo-5-phenyl-4H-1,3-oxazin-3-yl)-2-methylpropionaldehyde

Sources & evidence

ORD record: ord-13517bcc8c9c4b5fb43c5cf2eb14aee7
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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