Sodium ion → 8-(6-amino-4-chloropyridin-2-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

HRID 214907

Reaction equation

HRID 214907 reaction equation
[Br:12][c:13]1[c:14]2[n:15]([n:16][c:17]([Cl:19])[cH:18]1)[c:20]([C:23](=[O:24])[NH:25][c:26]1[c:27]([F:32])[cH:28][n:29][cH:30][cH:31]1)[cH:21][n:22]2.[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[Cl:1][c:2]1[cH:3][c:4]([NH2:9])[n:5][c:6]([NH2:8])[cH:7]1.[H-:11].[Na+:10].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[OH2:43]>>[Cl:1][c:2]1[cH:3][c:4]([NH:9][c:13]2[c:14]3[n:15]([n:16][c:17]([Cl:19])[cH:18]2)[c:20]([C:23](=[O:24])[NH:25][c:26]2[c:27]([F:32])[cH:28][n:29][cH:30][cH:31]2)[cH:21][n:22]3)[n:5][c:6]([NH2:8])[cH:7]1

Participants

8

Reactant 7

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 166653HydrideHCID 2378474-Chloropyridine-2,6-diamineHCID 596244958-Bromo-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

Product 1

HCID 596243518-(6-amino-4-chloropyridin-2-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

Sources & evidence

ORD record
ord-cf29112e10e44ae3b24c330e95e1be73
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

Loading…