Potassium Cation → 5-(Difluoromethoxy)-3-methylpicolinonitrile

Reaction equation

[CH3:30][CH2:31][O:32][C:33]([CH3:34])=[O:35].[Cl:11][C:12]([C:13]([O-:14])=[O:15])([F:16])[F:17].[K+:19].[K+:20].[Na+:18].[O-:21][C:22]([O-:23])=[O:24].[O:25]=[CH:26][N:27]([CH3:28])[CH3:29].[OH:1][c:2]1[cH:3][c:4]([CH3:10])[c:5]([C:8]#[N:9])[n:6][cH:7]1>>[O:1]([c:2]1[cH:3][c:4]([CH3:10])[c:5]([C:8]#[N:9])[n:6][cH:7]1)[CH:12]([F:16])[F:17]

Participants

Reactant 7

HCID 813Potassium Cation2×

HCID 923Sodium Ion

HCID 6228Dimethylformamide

HCID 8857Ethyl Acetate

HCID 19660Carbonate Ion

HCID 37630462-Chloro-2,2-difluoroacetate

HCID 299497345-Hydroxy-3-methylpyridine-2-carbonitrile

Product 1

HCID 666659915-(Difluoromethoxy)-3-methylpicolinonitrile

Sources & evidence

ORD record: ord-c8c34dbd3da94c4985cb09ac10e73bcd
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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