Chloride → (4-Benzyloxy-2-fluoro-5-methoxy-phenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

HRID 215067

Reaction equation

HRID 215067 reaction equation
[CH2:26]([c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1)[O:33][c:34]1[cH:35][c:36]([F:44])[c:37]([CH:38]=[O:39])[cH:40][c:41]1[O:42][CH3:43].[CH:22]([Mg+:23])([CH3:24])[CH3:25].[Cl-:21].[I:1][c:2]1[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12.[O:46]1[CH2:47][CH2:48][CH2:49][CH2:50]1.[OH2:45]>>[c:2]1([CH:38]([c:37]2[c:36]([F:44])[cH:35][c:34]([O:33][CH2:26][c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[c:41]([O:42][CH3:43])[cH:40]2)[OH:39])[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12

Participants

7

Reactant 6

HCID 312ChlorideHCID 962WaterHCID 8028TetrahydrofuranHCID 5614564-Benzyloxy-2-fluoro-5-methoxy-benzaldehydeHCID 242292273-Iodo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridineHCID 178461726HCID 178461726, compound

Product 1

HCID 58087295(4-Benzyloxy-2-fluoro-5-methoxy-phenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

Sources & evidence

ORD record
ord-3e98531bf75541538f59ecab1a65e7e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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