Tetrahydrofuran → 2-{[4-(4-Bromophenyl)-1,3-thiazol-2-yl]amino}-3,3,3-trifluoropropan-1-ol

Reaction equation

[Al+3:24].[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]([NH:13][CH:14]([C:15]([F:16])([F:17])[F:18])[C:19](=[O:20])[O:21][CH3:22])[s:11][cH:12]2)[cH:6][cH:7]1.[H-:23].[H-:26].[H-:27].[H-:28].[Li+:25].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]([NH:13][CH:14]([C:15]([F:16])([F:17])[F:18])[CH2:19][OH:20])[s:11][cH:12]2)[cH:6][cH:7]1

Participants

Reactant 5

HCID 8028Tetrahydrofuran

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 87617791Methyl 2-[[4-(4-bromophenyl)-1,3-thiazol-2-yl]amino]-3,3,3-trifluoropropanoate

Product 1

HCID 866185992-{[4-(4-Bromophenyl)-1,3-thiazol-2-yl]amino}-3,3,3-trifluoropropan-1-ol

Sources & evidence

ORD record: ord-7d3942fc8e4b415caad2bb327a265769
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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