1,2-Dichloroethane → 1-[4-(3-Pyrrolidin-1-ylmethyl-cyclobutyl)-benzyl]-pyrrolidine

Reaction equation

[CH3:24][S:25](=[O:26])(=[O:27])[OH:28].[CH3:29][OH:30].[Cl:31][CH2:32][CH2:33][Cl:34].[N:1]1([CH2:6][CH:7]2[CH2:8][C:9]([OH:11])([c:12]3[cH:13][cH:14][c:15]([CH2:18][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[cH:16][cH:17]3)[CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5]1>>[N:1]1([CH2:6][CH:7]2[CH2:8][CH:9]([c:12]3[cH:13][cH:14][c:15]([CH2:18][N:19]4[CH2:20][CH2:21][CH2:22][CH2:23]4)[cH:16][cH:17]3)[CH2:10]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

Reactant 4

HCID 111,2-Dichloroethane

HCID 887Methanol

HCID 6395Methanesulfonic Acid

HCID 219348323-Pyrrolidin-1-ylmethyl-1-(4-pyrrolidin-1-ylmethyl-phenyl)-cyclobutanol

Product 1

HCID 113125751-[4-(3-Pyrrolidin-1-ylmethyl-cyclobutyl)-benzyl]-pyrrolidine

Sources & evidence

ORD record: ord-4e6229364a9349368c8dab6eef3b4bea
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…