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Dichloromethane → Piperazine

HRID 2163
Notes
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Reaction equation

HRID 2163 reaction equation
[CH2:1]([Cl:3])Cl.[Cl:4][C:5]1[CH:6]=[C:7]([NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:23]=C[N:21]=[C:20]([N:24]4[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]4)[CH:19]=3)[CH:15]=[CH:14][N:13]=2)[CH:8]=[CH:9][CH:10]=1>CO>[Cl:4][C:5]1[CH:6]=[C:7]([NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:19]=[CH:20][N:21]=[C:1]([Cl:3])[CH:23]=3)[CH:15]=[CH:14][N:13]=2)[CH:8]=[CH:9][CH:10]=1.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 6344DichloromethaneHCID 21948237N-[3-chloro-phenyl]-4-[2-(1-piperazinyl)-4-pyridyl]-2-pyrimidineamine

Product 2

HCID 4837PiperazineHCID 9905031N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Analogously to Example 1, there is obtained from 100 mg (0.31 mmol) of N-[3-chloro-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine and 500 mg (5.63 mmol) of piperazine, from the melt after chromatography (methylene chloride:methanol=95:5), N-[3-chloro-phenyl]-4-[2-(1-piperazinyl)-4-pyridyl]-2-pyrimidineamine;

Sources & evidence

ORD record
ord-8b8f64beacb447798a17fed01f8b02fc
Source dataset
uspto-grants-1998_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05728708

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes