Triethylamine → 4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
Reaction equation
[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[NH:8][CH:7]=[N:6][CH:5]=1.[CH3:11][N:12]([CH3:17])[S:13](Cl)(=[O:15])=[O:14].CCN(CC)CC>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[N:8]=[CH:7][N:6]([S:13]([N:12]([CH3:17])[CH3:11])(=[O:15])=[O:14])[CH:5]=1Participants
6
Procedure
A solution of 5-(2,2-dimethylpropyl)-1H-imidazole, dimethylsulfamoyl chloride (25 mL), Et3N (45 mL) in CH2Cl2 (300 mL) was added DMAP (0.8 g). The reaction mixture was refluxed overnight. The solvent was evaporated and the residue was purified by silica gel chromatography to give the title compound as a white solid.
Workup
- temperatureThe reaction mixture was refluxed overnight
- customThe solvent was evaporated
- customthe residue was purified by silica gel chromatography
Sources & evidence
- ORD record
- ord-fce201cbc7b94f32b75c1ac10287c823
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08193228B2
Reaction notes
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