Reaction equation
[C:1]1(=[O:11])[O:6]C(=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.C1(=O)NC(=O)C2=CC=CC=C12.C(O)(=O)C1C(=CC=CC=1)N.[S-2].[Na+].[Na+].[S].C(S)(=S)C1C(=CC=CC=1)O.N.[NH4+].S1(C2C(=CC=CC=2)C(=O)N1)(=O)=O.[Cl:61]C1C=CC=CC=1C.[O-][Cr](O[Cr]([O-])(=O)=O)(=O)=O.[Na+].[Na+]>CO>[Cl:61][C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[C:1]([OH:6])=[O:11]Participants
Reactant 9
Product 1
Reagents, catalysts & solvents 1
Procedure
A further production process comprises converting phthalic acid anhydride into phthalimide and phthalimide into anthranilic acid, diazotising the anthranilic acid and reacting the diazotised product with sodium sulphide/sulphur to dithiosalicylic acid, esterifying the dithiosalicylic acid with methanol, and reacting the esterified product by means of oxidating chlorination to methyl benzoate-o-sulphonic acid chloride and subsequently converting this with ammonia into the saccharin ammonium salt. Another method consists of oxidising o-chlorotoluene with sodium bichromate to give o-chlorobenzoic acid, subsequently reacting this with sodium sulphite to o-sulphobenzoic acid, esterifying this with methanol and reacting the esterified product with thionyl chloride or sulphuryl chloride to methyl benzoate-o-sulphonic acid chloride, and converting this with ammonia into the saccharin ammonium salt.
Sources & evidence
- ORD record
- ord-818402e49d0947e6bbd193011cbdc65b
- Source dataset
- uspto-grants-1979_01
- Patent number
- US04135028
Linked notes
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