Ammonium Acetate → 1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181908

Reaction equation

HRID 2181908 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

Participants

5

Reactant 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224823721-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

Product 1

HCID 224823821-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from 1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (720 mg, 2.9 mmol), anhydrous methanol (10 mL), ammonium acetate (4.44 g, 58 mmol), and sodium cyanoborohydride (362 g, 5.8 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 114, step c;

Workup

  1. customThe crude amine was immediately used without further purification in Example 114, step c

Sources & evidence

ORD record
ord-aedbfb1c67b5452db02693817d12d88e
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Linked notes

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