Potassium Carbonate → 3,9-Difluoro-5-[(3-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

HRID 2181912

Reaction equation

HRID 2181912 reaction equation
F[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH:18][S:19]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)(=[O:21])=[O:20])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:8][C:6]1[CH:5]=[CH:4][C:3]2[C:9]3[C:10]([CH:16]([CH3:17])[N:18]([S:19]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=4)(=[O:20])=[O:21])[C:2]=2[CH:7]=1)=[CH:11][CH:12]=[C:13]([F:15])[CH:14]=3

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22482268N-[1-(2',4',5-Trifluoro-1,1'-biphenyl-2-yl)ethyl]-3-methoxybenzenesulfonamide

Product 1

HCID 224823263,9-Difluoro-5-[(3-methoxyphenyl)sulfonyl]-6-methyl-5,6-dihydrophenanthridine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared from N-[1-(2′,4′,5-trifluoro-1,1′-biphenyl-2-yl)ethyl]-3-methoxybenzenesulfonamide (234 mg, 0.55 mmol), anhydrous N,N-dimethylformamide (1 mL), and potassium carbonate (154 mg, 1.1 mmol) according to the procedure and in the same manner as described in Example 105, step d resulting in the isolation of 211 mg (95%) of a white solid. This material was used without further purification in Example 115, step c;

Sources & evidence

ORD record
ord-bb10fe8a06b84534b34877521a316640
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Linked notes

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