Ammonium Acetate → 1-(2',5',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

HRID 2181915Notes

Reaction equation

HRID 2181915 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[C:16](=O)[CH3:17].C([O-])(=O)C.[NH4+].C([BH3-])#[N:25].[Na+]>CO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[CH:16]([NH2:25])[CH3:17]

Participants

5

Reactant 3

HCID 517165Ammonium AcetateHCID 5003444Sodium cyanoborohydrideHCID 224822741-(2',5',5-Trifluoro-1,1'-biphenyl-2-yl)ethanone

Product 1

HCID 224822791-(2',5',5-Trifluoro-1,1'-biphenyl-2-yl)ethylamine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared from 1-(2′,5′,5-trifluoro-1,1′-biphenyl-2-yl)ethanone (650 mg, 2.6 mmol), anhydrous methanol (10 mL), ammonium acetate (4.0 g, 52 mmol), and sodium cyanoborohydride (326 g, 5.2 mmol) according to the procedure and in the same manner as described in Example 105, step b. The crude amine was immediately used without further purification in Example 116, step c;

Workup

  1. customThe crude amine was immediately used without further purification in Example 116, step c

Sources & evidence

ORD record
ord-85d4257011ad4af6afb5dfc5e879095a
Source dataset
uspto-grants-2005_05
Patent number
US06894061B2

Reaction notes

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