2,4,6-Tribromophenol → HCID 3303004, compound

HRID 2189960

Reaction equation

HRID 2189960 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[OH:10].Cl[CH2:12][C:13]([CH3:15])=[O:14].C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[C:4]([Br:9])[C:3]=1[O:10][CH2:12][C:13](=[O:14])[CH3:15]

Participants

6

Reactant 4

HCID 14832,4,6-TribromophenolHCID 6228DimethylformamideHCID 6571ChloroacetoneHCID 11430Potassium Carbonate

Product 1

HCID 3303004HCID 3303004, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
27 °C

Procedure

A mixture of 5 g 2,4,6-tribromophenol (15 mmol), 1.4 g 1-chloroacetone (15 mmol), 4.16 g anhydrous potassium carbonate (30 mmol) and 20 ml DMF is stirred at 27° C. Completion of the reaction is confirmed by TLC. The reaction mass is diluted with water and extracted with ethylacetate The organic layer is washed with water and brine, dried over anhydrous sodium sulphate and concentrated to obtain 5.6 g 1-(2,4,6-tribromo-phenoxy)-propan-2-one (97%).

Workup

  1. extractionextracted with ethylacetate The organic layer
  2. washis washed with water and brine
  3. dry with materialdried over anhydrous sodium sulphate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-38af585a78e94ac3a9c44895c8a11a23
Source dataset
uspto-grants-2012_12
Patent number
US08324263B2

Linked notes

Loading…