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Trifluoroacetic acid → HCID 67415912, compound

HRID 2205656
Notes
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Reaction equation

HRID 2205656 reaction equation
[Cl:1][C:2]1[N:3](CC2C=CC(OC)=CC=2)[CH:4]=[C:5]2[C:10]=1[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]2[CH2:14][CH:15]([CH3:17])[CH3:16].C(O)(C(F)(F)F)=O.C(S(O)(=O)=O)(F)(F)F>C(Cl)Cl>[Cl:1][C:2]1[NH:3][CH:4]=[C:5]2[C:10]=1[C:9](=[O:11])[N:8]([CH3:12])[C:7](=[O:13])[N:6]2[CH2:14][CH:15]([CH3:17])[CH3:16]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 62406Trifluoromethanesulfonic acidHCID 674146965-chloro-1-isobutyl-6-(4-methoxybenzyl)-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Product 1

HCID 67415912HCID 67415912, compoundYield 42.9%

Reagents, catalysts & solvents 1

HCID 6344Dichloromethane
Solvent

Procedure

Crude 5-chloro-1-isobutyl-6-(4-methoxybenzyl)-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (2.5 g) is dissolved in 5 mL of methylene chloride containing TFA (2 mL) and TFMSA (1.6 mL). The reaction mixture is stirred at room temperature overnight. After routine workup, the obtained crude product is purified by column chromatography to give 730 mg of product as gray solids. MS (ESI) m/z 256.1 [M+H]+.

Workup

  1. customAfter routine workup, the obtained crude product
  2. customis purified by column chromatography

Sources & evidence

ORD record
ord-5a9f72c12ec0449abd865666c943839e
Source dataset
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US09371327B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes