4-Chlorophenol → 1-(4-Chlorophenoxy)acetone

HRID 2221131

Reaction equation

HRID 2221131 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][C:11](=[O:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][C:11](=[O:13])[CH3:12])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 46844-ChlorophenolHCID 6571ChloroacetoneHCID 11430Potassium Carbonate

Product 1

HCID 2398741-(4-Chlorophenoxy)acetone

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A suspension of 4-chlorophenol (2.6 g, 20 mmol), chloroacetone (2.8 g, 30 mmol) and potassium carbonate (3.45 g, 25 mmol) in acetone (100 ml) is heated at reflux for 3 hours. The precipitating inorganic salts are filtered off and the filtrate is evaporated to dryness to give the 1-(4-chlorophenoxy)-propan-2-one.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 3 hours
  3. filtrationThe precipitating inorganic salts are filtered off
  4. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-65a19d1a749045648c581d1c864878ce
Source dataset
uspto-grants-2008_05
Patent number
US07368479B2

Linked notes

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