Triethylamine → Methyl 5-formyl-2-methanesulfonyloxybenzoate

Reaction equation

[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:13])=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=[O:2].C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(OCC)(=O)C>[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([O:13][S:22]([CH3:21])(=[O:24])=[O:23])=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=[O:2]

Participants

Procedure

To a mixture of methyl 5-formyl-2-hydroxybenzoate (21.76 g), triethylamine (13.46 g), ethyl acetate (300 mL) was added dropwise methanesulfonyl chloride (15.24 g) at 0° C., and the mixture was stirred at room temperature for 3 hr. The reaction mixture was washed successively with water, saturated aqueous sodium hydrogen carbonate, 1N hydrochloric acid and saturated brine, dried over anhydrous magnesium sulfate and concentrated to give methyl 5-formyl-2-methanesulfonyloxybenzoate as a colorless oil (31.20 g, yield 100%).