Sodium hydride → HCID 588994, compound
Reaction equation
Cl[CH2:2][CH2:3][N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=[CH:5]1.[H-].[Na+]>O1CCCC1>[CH:3]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]=[CH:5]1)=[CH2:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 3.61 g (20 mmoles) of 1-(2-chloroethyl)benzimidazole in 50 ml of tetrahydrofuran was added in portions 960 mg (20 mmoles) of 50% sodium hydride and the mixture allowed to stir for 3 hours. The solids were filtered, washed with tetrahydrofuran and the washings and filtrate evaporated to dryness. The residue was dissolved in acetonitrile, washed with hexane and the acetonitrile concentrated to give 2.77 g of product as a yellow oil.
Workup
- filtrationThe solids were filtered
- washwashed with tetrahydrofuran
- customthe washings and filtrate evaporated to dryness
- dissolutionThe residue was dissolved in acetonitrile
- washwashed with hexane
- concentrationthe acetonitrile concentrated
Sources & evidence
- ORD record
- ord-0c66a79fb5424b068d81e7f5fa123f41
- Source dataset
- uspto-grants-1988_11
- Patent number
- US04782050
Reaction notes
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