Methane → 4-(2-Hydroxyethyl)piperidin-4-ol
Reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][CH2:16][OH:17])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.C>CO.[OH-].[Pd+2].[OH-]>[OH:17][CH2:16][CH2:15][C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 60 °C
Procedure
To a solution of compound 25 (1.32 g, 5.30 mmol) in methanol (10 mL) under argon was added palladium hydroxide (20%) on activated charcoal (132 mg, 10% w/w). The solution was purged three times with hydrogen and stirred under hydrogen atmosphere at 60° C. for 4 hrs. The resulting solution was then filtered on celite plug to give desired compound 26 (790 mg, 94%) which was used as such for the next step.
Workup
- customThe solution was purged three times with hydrogen
- filtrationThe resulting solution was then filtered on celite plug
Sources & evidence
- ORD record
- ord-20a3b2871bac4ca9a93cbb31fd645e30
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709516B2
Reaction notes
Loading…