Isopropanol → 6-ethoxy-7-(3-hydroxypropoxy)-2H-1-benzopyran-2-one

HRID 22358

Reaction equation

HRID 22358 reaction equation
[CH2:1]([O:3][C:4]1[C:5]([OH:15])=[CH:6][C:7]2[O:12][C:11](=[O:13])[CH:10]=[CH:9][C:8]=2[CH:14]=1)[CH3:2].Cl[CH2:17][CH2:18][CH2:19][OH:20].C(O)(C)C>CC(OC)(C)C>[CH2:1]([O:3][C:4]1[C:5]([O:15][CH2:17][CH2:18][CH2:19][OH:20])=[CH:6][C:7]2[O:12][C:11](=[O:13])[CH:10]=[CH:9][C:8]=2[CH:14]=1)[CH3:2]

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 123133-Chloro-1-propanolHCID 199277146-ethoxy-7-hydroxy-2H-1-benzopyran-2-one

Product 1

HCID 199277366-ethoxy-7-(3-hydroxypropoxy)-2H-1-benzopyran-2-oneYield 69%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

Method K; starting materials: 6-ethoxy-7-hydroxy-2H-1-benzopyran-2-one and 3-chloro-1-propanol; yield 69%; fusion point 96°-98° C. (from isopropanol and TBME).

Sources & evidence

ORD record
ord-2120491cd3734273b49a4ac389fd8d89
Source dataset
uspto-grants-1995_06
Patent number
US05428038

Linked notes

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