Hydrochloric Acid → Fasudil

HRID 2238452

Reaction equation

HRID 2238452 reaction equation
[CH:1]1[CH:2]=[C:3]2[C:8](=[C:9]([S:11]([N:14]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])[CH:10]=1)[CH:7]=[CH:6][N:5]=[CH:4]2.Cl.[Cl-].[Na+].Cl.[OH-].[Na+]>O>[CH:1]1[CH:2]=[C:3]2[C:8](=[C:9]([S:11]([N:14]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])[CH:10]=1)[CH:7]=[CH:6][N:5]=[CH:4]2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 163751Fasudil Hydrochloride

Product 1

HCID 3547Fasudil

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Fasudil-hydrochloride ½ hydrate (3.08 g) and sodium chloride (0.8 g, manufactured by Wako Pure Chemical Industries, Ltd.) were dissolved in water (80 ml). After adjusting the pH of all solutions to 1, 2, 3, 4, 5, 6, 7, 7.5, 8, and 9 by addition of a diluted hydrochloric acid or sodium hydroxide reagent solution, the volume of each solution was adjusted to 100 ml by addition of water. The fasudil hydrochloride aqueous solutions were aseptically filtered and 2 ml of the filtrates were filled in transparent and colorless glass ampoules (2 ml (manufactured by Namicos Corp.)). The ampoules were melt-sealed to obtain fasudil-containing preparations with the pH of 1-9 (hereinafter referred to as “fasudil hydrochloride-containing preparations”).

Workup

  1. filtrationThe fasudil hydrochloride aqueous solutions were aseptically filtered
  2. addition2 ml of the filtrates were filled in transparent and colorless glass ampoules (2 ml (manufactured by Namicos Corp.))
  3. customThe ampoules were melt-sealed

Sources & evidence

ORD record
ord-0caff890e69044238c002ca53048d100
Source dataset
uspto-grants-2010_05
Patent number
US07718797B2

Linked notes

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