Triethyl Citrate → Ethyl Acetoacetate

HRID 22441

Reaction equation

HRID 22441 reaction equation
C(OCC)(=O)[CH2:2][C:3]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])(C(OCC)=O)[OH:4]>CC([O-])C.CC([O-])C.CC([O-])C.CC([O-])C.[Ti+4]>[C:11]([O:13][CH2:14][CH3:15])(=[O:12])[CH2:10][C:3]([CH3:2])=[O:4]

Participants

3

Reactant 1

HCID 6506Triethyl Citrate

Product 1

HCID 8868Ethyl Acetoacetate

Reagents, catalysts & solvents 1

HCID 11026Titanium isopropoxideCatalyst

Procedure

In the same way as in Example 1, 60 g (0.21 mol) of tetraisopropyl titanate were reacted with 116.6 g (0.42 mol) of triethyl citrate. The mixture was freed of alcohol under vacuum and 154.6 g of a clear, pale yellow liquid was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-0b1f2e1c0f294ff991c72bb3ca95134c
Source dataset
uspto-grants-1995_06
Patent number
US05428103

Linked notes

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