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Water → HCID 43152087, compound

HRID 2245522
Notes
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Reaction equation

HRID 2245522 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[CH:7]2)([O-:3])=[O:2].Br[CH2:14][C:15]([O:17][CH3:18])=[O:16].C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[N:9]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH:8]=[CH:7]2)([O-:3])=[O:2]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 10796Cesium carbonateHCID 225235-NitroindoleHCID 60984Methyl bromoacetate

Product 1

HCID 43152087HCID 43152087, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes

A mixture of 5-nitroindole (3.24 g, 20 mmol), methyl bromoacetate (3.36 g, 22 mmol), cesium carbonate (32.58 g, 100 mmol) in 150 mL of DMF was stirred at room temperature for 3 h. The reaction mixture was poured into water and the solid was collected and dried to give methyl (5-nitro-1H-indol-1-yl)acetate as a pale yellow solid: MS (ESI) m/z 235.

Workup

  1. customthe solid was collected
  2. customdried

Sources & evidence

ORD record
ord-69a1c19affed40ccb424adcadb19663f
Source dataset
uspto-grants-2010_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07683091B2

Reaction notes

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