Triethylamine → 5-({[t-Butyl(dimethyl)silyl]oxy}methyl)-3-ethylthiophene-2-carbonitrile

To a suspension of 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-3-ethylthiophene-2-carboxaldehyde (1.3 g, 4.8 mmol) that was obtained in Example 10 (10b) and hydroxylamine hydrochloride (0.37 g, 5.3 mmol) in dichloromethane (20 ml) were added successively methanol (2 ml) and triethylamine (1.3 ml, 9.6 mmol) with stirring, and the resulting mixture was stirred at room temperature for 2 hours. After removing the solvent in vacuo, toluene (10 ml) was added to the residue and the resulting mixture was evaporated azeotropically in vacuo. Subsequently, the residue obtained and N,N′-dicyclohexylcarbodiimide (1.1 g, 5.3 mmol) were suspended in toluene (20 ml) and stirred at 90° C. for 15 hours. After cooling to room temperature, hexane (20 ml) was added to the reaction mixture, and the resulting mixture was filtered with Celite. The filtrate was evaporated in vacuo, and the crude product of the title compound thus obtained was purified by chromatography on a silica gel column using a mixed solvent of ethyl acetate and hexane (0:10 to 5:95) as the eluent to afford the title compound (0.94 g) in a yield of 69% as a pale yellow oily product.

1. stirringthe resulting mixture was stirred at room temperature for 2 hours
2. customAfter removing the solvent in vacuo, toluene (10 ml)
3. additionwas added to the residue
4. customthe resulting mixture was evaporated azeotropically in vacuo
5. customSubsequently, the residue obtained
6. stirringstirred at 90° C. for 15 hours
7. filtrationthe resulting mixture was filtered with Celite
8. customThe filtrate was evaporated in vacuo

ORD record

ord-c2f824430b494d92801d493275193fd9

Source dataset

uspto-grants-2010_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07687491B2