3,4-dihydro-2H-pyran → 5,5-Dimethyl-3-tetrahydropyranyloxy-1-octyne

HRID 225361

Reaction equation

HRID 225361 reaction equation
[CH3:1][C:2]([CH3:11])([CH2:8][CH2:9][CH3:10])[CH2:3][CH:4]([OH:7])[C:5]#[CH:6].[O:12]1[CH:17]=[CH:16][CH2:15][CH2:14][CH2:13]1>P(Cl)(Cl)(Cl)=O>[CH3:1][C:2]([CH3:11])([CH2:8][CH2:9][CH3:10])[CH2:3][CH:4]([O:7][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][O:12]1)[C:5]#[CH:6]

Participants

4

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 204655895,5-Dimethyl-1-octyn-3-ol

Product 1

HCID 538897305,5-Dimethyl-3-tetrahydropyranyloxy-1-octyne

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideCatalyst

Procedure

Treatment of 23.1 g. (0.150 mole) of 5,5-dimethyl-1-octyne-3-ol (Example 153) with 126 g. of dihydropyran and 1 drop of phosphorus oxychloride as described in Example 150 gives the title compound.

Sources & evidence

ORD record
ord-d796d6559b2b4251a5e771e9396930ce
Source dataset
uspto-grants-1980_11
Patent number
US04236027

Linked notes

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