[CH2:1]([C:4]1[NH:8][N:7]=[C:6]([NH:9][C:10](=[N:12]O)[CH3:11])[CH:5]=1)[CH2:2][CH3:3].N1C=CC=CC=1.C1(C)C=CC(S(Cl)(=O)=O)=CC=1.O>CN(C)C(=O)C>[CH3:11][C:10]1[NH:9][C:6]2[N:7]([N:8]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:5]=2)[N:12]=1A 5.38 g portion of N-(5-propyl-1H-pyrazol-3-yl)acetamidoxime was dissolved in 45 ml of N,N-dimethylacetamide. With cooling on an ice bath, to this were added 2.39 ml of pyridine and 5.63 g of p-toluenesulfonic acid chloride, followed by 30 minutes of stirring at the same temperature and additional 3 hours of stirring at room temperature. The resulting reaction mixture was added to 350 ml of water and extracted with chloroform. After distilling off chloroform from the organic layer under a reduced pressure, the thus obtained residue was dissolved in 135 ml of methanol, mixed with 2.39 ml of pyridine and then heated under reflux for 2 hours.
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