Triethylamine → 1,3-Dioxolan-4-ylmethyl methanesulfonate

HRID 227398

Reaction equation

HRID 227398 reaction equation
[CH2:1]1[O:5][CH2:4][O:3][CH:2]1[CH2:6][OH:7].C(N(CC)CC)C.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>C1COCC1>[CH3:15][S:16]([O:7][CH2:6][CH:2]1[CH2:1][O:5][CH2:4][O:3]1)(=[O:18])=[O:17]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 216181,3-Dioxolane-4-methanolHCID 31297Methanesulfonyl chloride

Product 1

HCID 871455181,3-Dioxolan-4-ylmethyl methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The glycerol formal (Aldrich, 0.26 g, 2.5 mmol), triethylamine (1.1 mL, 8.3 mmol), and methanesulfonyl chloride (0.30 mL, 3.7 mmol) in 20 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-8fa5e47351eb4d72a032b15200704450
Source dataset
uspto-grants-2009_07
Patent number
US07560481B2

Linked notes

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