2-Amino-4-methylpyridine → [2-(3,4-Dimethoxyphenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]-(6-isocyanohexyl)-amine

HRID 22806

Reaction equation

HRID 22806 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[N+:9]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N+:17]#[C-:18])#[C-:10].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[CH:24]=O>Cl(O)(=O)(=O)=O>[CH3:19][O:20][C:21]1[CH:22]=[C:23]([C:24]2[N:1]=[C:2]3[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]3[C:10]=2[NH:9][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N+:17]#[C-:18])[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]

Participants

5

Reactant 3

HCID 15332-Amino-4-methylpyridineHCID 8419VeratraldehydeHCID 33911051,6-Diisocyanohexane

Product 1

HCID 22591917[2-(3,4-Dimethoxyphenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]-(6-isocyanohexyl)-amine

Reagents, catalysts & solvents 1

HCID 24247Perchloric AcidSolvent

Procedure

Compound (24) was prepared according to the general synthesis instructions from 1.0 ml of 2-amino-4-methylpyridine solution (0.1 M, DCM), 0.575 ml of 1,6-diisocyanhexane solution (0.2 M, DCM), 0.500 ml of 3,4-dimethoxybenzaldehyde solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%).

Sources & evidence

ORD record
ord-69da732a5c2f44f58af76bcf57f85822
Source dataset
uspto-grants-2005_02
Patent number
US06849642B2

Linked notes

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