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Potassium Carbonate → HCID 20461182, compound

HRID 2287238
Notes
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Reaction equation

HRID 2287238 reaction equation
[CH3:1][C:2]1[CH2:7][CH2:6][N:5]([CH:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:11])=[O:10])[CH2:4][CH:3]=1.[O:15]([C:22]1[N:27]=[C:26]([CH2:28]Br)[CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.CCOCC>[CH3:1][C:2]1[CH2:7][CH2:6][N:5]([CH:8]([CH:12]([CH3:14])[CH3:13])[C:9]([O:11][CH2:28][C:26]2[CH:25]=[CH:24][CH:23]=[C:22]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:27]=2)=[O:10])[CH2:4][CH:3]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 129263872-(Bromomethyl)-6-phenoxypyridineHCID 20461196HCID 20461196, compound

Product 1

HCID 20461182HCID 20461182, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228
Dimethylformamide
Solvent

Procedure

The resulting 2-(4-methyl-1,2,5,6-tetrahydro-1-pyridyl)-3-methylbutanoic acid (7.0 mmol) is combined with (6-phenoxy-2-pyridyl)methyl bromide (7.0 mmol) and potassium carbonate (14.0 mmol) in 15 ml dimethylformamide, and the mixture is stirred at RT, under nitrogen, for 20 hours. The solution is brought up in ether, washed with water (3×) and brine, and dried over sodium sulfate to give (6-phenoxy-2-pyridyl)methyl 2-(4-methyl-1,2,5,6-tetrahydro-1-pyridyl)-3-methylbutanoate.

Workup

  1. washwashed with water (3×) and brine
  2. dry with materialdried over sodium sulfate

Sources & evidence

ORD record
ord-1d97e004c0414c0d98e9179a60bb33cb
Source dataset
uspto-grants-1981_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04269981

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes