Hydrochloric Acid → HCID 20031799, compound
Reaction equation
C([O:4][C:5]1[CH:24]=[CH:23][C:8]([C:9]([O:11][C:12]2[C:17]([F:18])=[C:16]([F:19])[C:15]([F:20])=[C:14]([F:21])[C:13]=2[F:22])=[O:10])=[CH:7][CH:6]=1)(=O)C.Cl>O1CCCC1>[OH:4][C:5]1[CH:24]=[CH:23][C:8]([C:9]([O:11][C:12]2[C:13]([F:22])=[C:14]([F:21])[C:15]([F:20])=[C:16]([F:19])[C:17]=2[F:18])=[O:10])=[CH:7][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Pentafluorophenyl 4-acetoxybenzoate (10 g) in tetrahydrofuran was treated with 50 ml of 5M hydrochloric acid and 150 ml of tetrahydrofuran and stirred at room temperature overnight. The solvents were evaporated in vacuo to give a product which was purified by column chromatography (silica; ethyl acetate/hexane mixtures as eluant) to afford the title compound (8 g).