Dimethyl Sulfoxide → HCID 14326857, compound

HRID 2291949Notes

Reaction equation

HRID 2291949 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH:18]([CH3:19])[CH2:17][CH:16]([OH:20])[CH2:15]3)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.C(Cl)(=O)C(Cl)=O.CS(C)=O.C(N(CC)CC)C>ClCCl>[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH:18]([CH3:19])[CH2:17][C:16](=[O:20])[CH2:15]3)(=[O:12])=[O:13])[C:5]=2[CH:4]=[CH:3][N:2]=1

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 212783201-(5-Isoquinolinesulfonyl)-3-hydroxy-5-methylpyrrolidine

Product 1

HCID 14326857HCID 14326857, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Then, in substantially the same manner as in Example 9, 2.34 g of the thus obtained 1-(5-isoquinolinesulfonyl)-3-hydroxy-5-methylpyrrolidine was reacted in dichloromethane with 1.08 g of oxalyl chloride, 0.67 g of dimethylsulfoxide and 0.60 g of triethylamine to obtain 1-(5-isoquinolinesulfonyl)-5-methyl-3-pyrrolidone.

Sources & evidence

ORD record
ord-b459180677ee4d34ba8d53b34902e5e5
Source dataset
uspto-grants-1989_01
Patent number
US04798897

Reaction notes

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