2,4-Dimethylpyridine → 2,4-Lutidine trifluoromethanesulfonate
Reaction equation
[F:1][C:2]([F:8])([F:7])[S:3]([OH:6])(=[O:5])=[O:4].[N:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[CH3:16]>C(O)C>[F:1][C:2]([F:8])([F:7])[S:3]([OH:6])(=[O:5])=[O:4].[N:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[CH3:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Eight-point-five grams of trifluoromethanesulfonic acid was added dropwise to a solution of 6.1 g of 2,4-lutidine in 15 ml of ethanol at 0° C. The solution was returned to room temperature, stirred overnight, and dried in vacuo at 60° C. for 16 hours to yield 2,4-lutidine trifluoromethanesulfonate (Lut+TfS−) as a colorless transparent liquid. The resulting salt had a melting point of 64.9° C.
Workup
- customwas returned to room temperature
- customdried in vacuo at 60° C. for 16 hours
Sources & evidence
- ORD record
- ord-99a3d7ee460a48208cc7a745934dabc9
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07563850B2
Reaction notes
Loading…