Hydrochloric Acid → 1-Methanesulfonylpiperazine hydrochloride

HRID 22959

Reaction equation

HRID 22959 reaction equation
CS([Cl:5])(=O)=O.C(N1CCNCC1)=O.C([N:16]1[CH2:21][CH2:20][N:19]([S:22]([CH3:25])(=[O:24])=[O:23])[CH2:18][CH2:17]1)=O.Cl>C(N(CC)CC)C.C(Cl)Cl>[ClH:5].[CH3:25][S:22]([N:19]1[CH2:20][CH2:21][NH:16][CH2:17][CH2:18]1)(=[O:24])=[O:23]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 821911-PiperazinecarboxaldehydeHCID 176120694-Methanesulfonylpiperazine-1-carbaldehyde

Product 1

HCID 162656121-Methanesulfonylpiperazine hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

Methanesulfonyl chloride (3.65 ml) was added to a methylene chloride (50 ml) solution containing N-formylpiperazine (5.08 g) and triethylamine (6.85 ml) under ice-cooling, and the mixture was stirred at room temperature for 18 hours to undergo reaction, thereby obtaining 1-formyl-4-methanesulfonylpiperazine. This compound was acid-treated with hydrochloric acid to obtain 1-methanesulfonylpiperazine.hydrochloride. Also, 1-(phenylsulfonyl)piperazine.hydrochloride was obtained in the same manner as mentioned above by using the corresponding starting material.

Workup

  1. temperaturecooling
  2. customreaction

Sources & evidence

ORD record
ord-86ffdc364ef24e92bca6c80b136177c6
Source dataset
uspto-grants-2005_02
Patent number
US06849622B2

Linked notes

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