Dimethylformamide → HCID 18388548, compound

To a cold (0° C.) stirred solution of 4-bromo-4′-heptyloxybiphenyl (6.21 g, 17.9 mmol) in THF (120 ml) was added n-BuLi (1.66 M solution in hexane, 32.3 ml, 53.6 mmol). After the mixture was stirred at 0° C. for 20 min., DMF (4.85 ml, 62.6 mmol) was added at −78° C. The mixture was stirred at −78° C. for additional 20 min., and then quenched with sat. aqueous NH4Cl. The mixture was diluted with EtOAc (220 ml), and then successively washed with sat. aqueous NH4Cl. (125 ml) and sat. brine (100 ml). The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:20) to give 4-formyl-4′-heptyloxybiphenyl (2.21 g, 42%) as a white amorphous powder.

1. stirringThe mixture was stirred at −78° C. for additional 20 min.
2. customquenched with sat. aqueous NH4Cl
3. additionThe mixture was diluted with EtOAc (220 ml)
4. washsuccessively washed with sat. aqueous NH4Cl
5. dry with materialThe organic layer was dried over anhydrous Na2SO4
6. concentrationconcentrated in vacuo
7. customThe residue was purified by column chromatography on silica gel (EtOAc/hexane, 1:20)

ORD record

ord-d0d3d29f2b8248e089957be5a1d8d772

Source dataset

uspto-grants-2002_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06489440B1