Ammonia → 1-(2-Methyl-8-quinolyl)-2,3,4,5-tetramethylcyclopentadiene

HRID 2304944

Reaction equation

HRID 2304944 reaction equation
Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[Li]CCCC.[CH3:18][C:19]1[C:20](=O)[CH:21]([CH3:26])[CH:22]([CH3:25])[C:23]=1[CH3:24].Cl.N>C1COCC1>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([C:20]3[CH:19]([CH3:18])[C:23]([CH3:24])=[C:22]([CH3:25])[C:21]=3[CH3:26])[CH:3]=[CH:4][CH:5]=2)[N:10]=1

Participants

7

Reactant 5

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 410922,3,4,5-Tetramethyl-2-cyclopentenoneHCID 47150308-Bromo-2-methylquinolineHCID 178418339Butyllithium

Product 1

HCID 223521291-(2-Methyl-8-quinolyl)-2,3,4,5-tetramethylcyclopentadieneYield 60%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4.4 g of 8-bromo-2-methylquinoline (20 mmol) in 50 ml of THF was cooled to −78° C., and 8.8 ml of n-BuLi (2.5 M in hexane, 22 mmol) were added dropwise with stirring. After the mixture had been stirred for 10 minutes, 3.5 g of 2,3,4,5-tetramethylcyclopentenone (25 mmol) were added dropwise, and the solution was warmed to room temperature, refluxed for one hour and cooled. Ice and hydrochloric acid were added to about pH 1, the mixture was neutralized using ammonia solution, the phases were separated, and the aqueous phase was extracted with pentane. After the combined organic extracts had been dried, the pentane was removed under reduced pressure, and the brown oil which remained was distilled under a high vacuum (b.p.: 115° C./0.01 mbar). 1-(2-Methyl-8-quinolyl)-2,3,4,5-tetramethylcyclopentadiene was obtained as a yellow, viscous oil in a yield of 60% (3.2 g).

Workup

  1. stirringAfter the mixture had been stirred for 10 minutes
  2. temperaturerefluxed for one hour
  3. temperaturecooled
  4. customthe phases were separated
  5. extractionthe aqueous phase was extracted with pentane
  6. customAfter the combined organic extracts had been dried
  7. customthe pentane was removed under reduced pressure
  8. distillationthe brown oil which remained was distilled under a high vacuum (b.p.: 115° C./0.01 mbar)

Sources & evidence

ORD record
ord-9767f2f0e12444d6a9971153fe47c1a5
Source dataset
uspto-grants-2002_08
Patent number
US06437161B1

Linked notes

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