Hydrochloric Acid → HCID 70105295, compound

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:41])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][CH:20]=[C:19]2[C:24]2[O:25][C:26]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:28]=2)[CH:12]=1.[ClH:42]>C(OCC)C.CCOC(C)=O>[ClH:42].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10](=[O:41])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][C@@H:18]2[CH2:23][CH2:22][CH2:21][CH:20]=[C:19]2[C:24]2[O:25][C:26]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)=[C:27]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[N:28]=2)[CH:12]=1

Participants

Procedure

To a solution of (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide (130 mg, 0.241 mmol) in ethyl ether (4 ml) was added 4N hydrogen chloride in EtOAc (0.5 ml) at room temperature. The solvent was removed in vacuo and the resulting solid was collected, washed with ethyl ether, and dried to give (S)-N-[2-(2-pyridyl)ethyl]-3-{[2-(4,5-diphenyloxazol-2-yl)-2-cyclohexen-1-yl]methyl}benzamide hydrochloride (135.2 mg, 97%).