Water → 6'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

HRID 230893

Reaction equation

HRID 230893 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21].O>CC(C)=O>[OH:1][C:2]1[C:3]([C:9](=[O:11])[CH3:10])=[C:4]([O:8][CH2:19][C:20]([O:22][CH3:23])=[O:21])[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 696872',6'-Dihydroxyacetophenone

Product 1

HCID 105370846'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a mixture of 2′,6′-dihydroxyacetophenone (6 g) and potassium carbonate (5.72 g) in acetone (20 mL) was added methyl bromoacetate (3.73 mL), and the mixture was stirred at room temperature for 5 days. To the reaction mixture was added water, and the precipitated crystals were collected by filtration. The crystals were washed with water and dried under reduced pressure to give the title compound (7.89 g).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-9697439f8c5f4eaf8fdafdd370708a5d
Source dataset
uspto-grants-2009_07
Patent number
US07566699B2

Linked notes

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