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Water → 6'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

HRID 230893
Notes
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Reaction equation

HRID 230893 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[O:11])[CH3:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21].O>CC(C)=O>[OH:1][C:2]1[C:3]([C:9](=[O:11])[CH3:10])=[C:4]([O:8][CH2:19][C:20]([O:22][CH3:23])=[O:21])[CH:5]=[CH:6][CH:7]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 696872',6'-Dihydroxyacetophenone

Product 1

HCID 105370846'-Hydroxy-2'-(methoxycarbonylmethoxy)acetophenone

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent
On this pageParticipantsProcedureWorkupSources & evidenceReaction notes

Procedure

To a mixture of 2′,6′-dihydroxyacetophenone (6 g) and potassium carbonate (5.72 g) in acetone (20 mL) was added methyl bromoacetate (3.73 mL), and the mixture was stirred at room temperature for 5 days. To the reaction mixture was added water, and the precipitated crystals were collected by filtration. The crystals were washed with water and dried under reduced pressure to give the title compound (7.89 g).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washThe crystals were washed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-9697439f8c5f4eaf8fdafdd370708a5d
Source dataset
uspto-grants-2009_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07566699B2

Reaction notes

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