Dimethylformamide → HCID 13555831, compound

To a -78° C. solution of the oxazoline derivative (7.8 g, 40.4 mmol), prepared from 3-fluorobenzoic acid in tne usual manner, in THF (50 mL) was added over 15 min sec-BuLi (29 mL of 1.4 M solution). After 30 min, DMF (6.3 mL) was added, and the reaction mixture was stirred at -78° C. for 2 hr. Tne reaction was then quenched with water (10 mL), and the mixture was acidified witn HCl and allowed to stir for 12 hr. The layers were separated, the aqueous layer was extracted with EtOAc, and the combined organic layer was concentrated in vacuo. Tnis material was dissolved in 5% KOH (50 mL), and the base layer was washed with Et2O (2×100 mL) to remove neutrals. The resulting base layer was added to 0° C. solution of concentrated HCl (25 mL), and the resulting cold acidic solution was extracted with EtOAc (3×75 mL). Workup and drying gave a tacky yellow solid (4.4 g) which was recrystallized from CHCl3 to give the title compound (1.97 g, 30%), mp 97°-100° C.

1. customTne reaction was then quenched with water (10 mL)
2. stirringto stir for 12 hr
3. customThe layers were separated
4. extractionthe aqueous layer was extracted with EtOAc
5. concentrationthe combined organic layer was concentrated in vacuo
6. dissolutionTnis material was dissolved in 5% KOH (50 mL)
7. washthe base layer was washed with Et2O (2×100 mL)
8. customto remove neutrals
9. additionThe resulting base layer was added to 0° C. solution of concentrated HCl (25 mL)
10. extractionthe resulting cold acidic solution was extracted with EtOAc (3×75 mL)
11. customWorkup and drying

ORD record

ord-d7d895e5e12b4d96852722f03593a5b9

Source dataset

uspto-grants-1987_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04697005