Pyridine → N-(4-chloro-2-methoxyphenyl)thiophene-2-sulfonamide

Reaction equation

[CH2:26]([Cl:27])[Cl:28].[NH2:1][c:2]1[c:3]([O:9][CH3:10])[cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[cH:20]1[cH:21][cH:22][n:23][cH:24][cH:25]1.[s:11]1[c:12]([S:16](=[O:17])(=[O:18])[Cl:19])[cH:13][cH:14][cH:15]1>>[NH:1]([c:2]1[c:3]([O:9][CH3:10])[cH:4][c:5]([Cl:8])[cH:6][cH:7]1)[S:16]([c:12]1[s:11][cH:15][cH:14][cH:13]1)(=[O:17])=[O:18]

Participants

Reactant 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 7143Benzenamine, 4-chloro-2-methoxy-

HCID 855182-Thiophenesulfonyl chloride

Product 1

HCID 69218506N-(4-chloro-2-methoxyphenyl)thiophene-2-sulfonamide

Sources & evidence

ORD record: ord-b3d42922de9b4450a62675d3c3237330
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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