Dimethylformamide → (4-Chloromethyl-pyridin-2-yl)-(5-phenyl-thiazol-2-yl)-amine

Reaction equation

[CH3:21][N:22]([CH3:23])[CH:24]=[O:25].[Cl:31][CH2:32][Cl:33].[P:26]([Cl:27])([Cl:28])([Cl:29])=[O:30].[c:1]1(-[c:7]2[cH:8][n:9][c:10]([NH:12][c:13]3[n:14][cH:15][cH:16][c:17]([CH2:19][OH:20])[cH:18]3)[s:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[cH:8][n:9][c:10]([NH:12][c:13]3[n:14][cH:15][cH:16][c:17]([CH2:19][Cl:28])[cH:18]3)[s:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 6344Dichloromethane

HCID 24813Phosphorus oxychloride

HCID 11150268[2-(5-Phenyl-thiazol-2-ylamino)-pyridin-4-yl]-methanol

Product 1

HCID 11335641(4-Chloromethyl-pyridin-2-yl)-(5-phenyl-thiazol-2-yl)-amine

Sources & evidence

ORD record: ord-b5828492a049417cb84d29e86ead02ef
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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