Tetrahydrofuran → 2-Chloromethyl-6-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine

Reaction equation

[Al+3:26].[CH3:1][c:2]1[c:3]([CH2:13][O:14][c:15]2[cH:16][cH:17][cH:18][c:19]([C:21]([O:22][CH3:23])=[O:24])[n:20]2)[n:4][c:5](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[o:6]1.[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1.[S:31]([Cl:32])([Cl:33])=[O:34]>>[CH3:1][c:2]1[c:3]([CH2:13][O:14][c:15]2[cH:16][cH:17][cH:18][c:19]([CH2:21][Cl:33])[n:20]2)[n:4][c:5](-[c:7]2[cH:8][cH:9][cH:10][cH:11][cH:12]2)[o:6]1

Participants

Reactant 6

HCID 8028Tetrahydrofuran

HCID 24386Thionyl Chloride

HCID 28486Lithium ion

HCID 104727Aluminum Cation

HCID 166653Hydride4×

HCID 17861391Methyl 6-(5-methyl-2-phenyl-4-oxazolyl)methoxy-2-pyridinecarboxylate

Product 1

HCID 17861302

Sources & evidence

ORD record: ord-48bb9050da9648f187222b45c680353a
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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