Bromide ion → 2-(3-Chloro-5-fluorophenyl)-5-pentylpyrimidine

Reaction equation

[Br-:1].[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[Cl:11][c:12]1[cH:13][c:14]([Br:15])[cH:16][c:17]([F:18])[cH:19]1.[Cl:21][c:22]1[n:23][cH:24][c:25]([CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[cH:26][n:27]1.[Cl:2][c:3]1[cH:4][c:5]([Mg+:10])[cH:6][c:7]([F:9])[cH:8]1.[ClH:33].[Mg:20]>>[Cl:2][c:3]1[cH:4][c:5](-[c:22]2[n:23][cH:24][c:25]([CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[cH:26][n:27]2)[cH:6][c:7]([F:9])[cH:8]1

Participants

Reactant 7

HCID 259Bromide ion

HCID 313Hydrochloric Acid

HCID 3283Diethyl Ether

HCID 27362231-Bromo-3-chloro-5-fluorobenzene

HCID 5462224Magnesium

HCID 167565262-Chloro-5-pentylpyrimidine

HCID 178505946HCID 178505946, compound

Product 1

Sources & evidence

ORD record: ord-17861e450b394426aa7e051a7adb7a8e
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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