Isopropanol → HCID 20032021, compound

Reaction equation

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:3]=1.[Na].[CH:14]([OH:17])([CH3:16])[CH3:15]>>[CH:14]([O:17][C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH:12]=[CH:11][CH:10]=[N:9]2)[CH:3]=1)([CH3:16])[CH3:15]

Participants

Reactant 3

HCID 3776Isopropanol

HCID 5360545Sodium

HCID 106312394-Chloro-6-(1H-pyrazol-1-yl)pyrimidine

Product 1

HCID 20032021HCID 20032021, compound

Procedure

Following the procedure of Example 15, 180 mg of 6-chloro-4-(1-pyrazolyl)pyrimidine was reacted with 23 mg of sodium metal and 3 ml of anhydrous isopropylalcohol to yield 127 mg of an oily substance, 6-isopropoxy-4-(1-pyrazolyl)pyrimidine,

Sources & evidence

ORD record: ord-1296cb7ec74a4192a79345e6c0e218ca
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04849424

Reaction notes

Loading…