Tetrahydrofuran → 3-[1-[6-(2,4-Difluorophenyl)pyridin-2-yl]-2-oxo-4-(trimethylsilyl)but-3-yn-1-yl]-4-fluorobenzonitrile
Reaction equation
[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:26][Si:27]([N-:28][Si:29]([CH3:30])([CH3:31])[CH3:32])([CH3:33])[CH3:34].[CH3:35][Si:36]([C:37]#[C:38][C:39](=[O:40])[O:41][CH2:42][CH3:43])([CH3:44])[CH3:45].[F:1][c:2]1[c:3](-[c:9]2[cH:10][cH:11][cH:12][c:13]([CH2:15][c:16]3[cH:17][c:18]([C:19]#[N:20])[cH:21][cH:22][c:23]3[F:24])[n:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[Li+:25]>>[F:1][c:2]1[c:3](-[c:9]2[cH:10][cH:11][cH:12][c:13]([CH:15]([c:16]3[cH:17][c:18]([C:19]#[N:20])[cH:21][cH:22][c:23]3[F:24])[C:39]([C:38]#[C:37][Si:36]([CH3:35])([CH3:44])[CH3:45])=[O:40])[n:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1
