Iodoethane → 2-Ethylbenzo[b]thiophene

HRID 234330

Reaction equation

HRID 234330 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li][C:11](C)(C)[CH3:12].ICC>C1COCC1>[CH2:11]([C:5]1[S:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH:4]=1)[CH3:12]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 7221Benzo(B)ThiopheneHCID 178418306HCID 178418306, compound

Product 1

HCID 5956642-Ethylbenzo[b]thiophene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Ethylbenzo[b]thiophene was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7M, 8.9 mmoles, 5.3 ml), iodoethane (8.9 mmoles, 0.72 ml) and THF (20 ml). 1.2 g (99%) of a yellow liquid was isolated.

Sources & evidence

ORD record
ord-12ece86c36f14ae9b86f3487d2895506
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Linked notes

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