Phosphate → 2-Amino-6-tert-butyl-benzothiazole-4-thiol

HRID 23461

Reaction equation

HRID 23461 reaction equation
[C:1]([C:5]1[CH:14]=[C:13]([S:15]C#N)[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].SC[C@H]([C@@H](CS)O)O.P([O-])([O-])([O-])=O>CCO>[NH2:12][C:10]1[S:11][C:7]2[C:8](=[C:13]([SH:15])[CH:14]=[C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])[CH:6]=2)[N:9]=1

Participants

5

Reactant 3

HCID 1061PhosphateHCID 446094D-1,4-DithiothreitolHCID 154738426-Tert-butyl-4-thiocyanato-benzothiazol-2-yl-amine

Product 1

HCID 225727802-Amino-6-tert-butyl-benzothiazole-4-thiol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared according to General Method 14 using 6-tert-butyl-4-thiocyanato-benzothiazol-2-yl-amine (Example L-6; 2.0 g. 7.6 mmol), dithiothreitol (4.6 g, 30 mmol), phosphate buffer of pH 7 (10 mL), and EtOH (50 mL). The crude product was used further without any purification. MS (APCI): 239 (M+H).

Workup

  1. customThe crude product was used further without any purification

Sources & evidence

ORD record
ord-c023bb652b76466495c6fd9c9529320f
Source dataset
uspto-grants-2005_02
Patent number
US06852711B2

Linked notes

Loading…