Phosphate → 2-Amino-6-tert-butyl-benzothiazole-4-thiol
Reaction equation
[C:1]([C:5]1[CH:14]=[C:13]([S:15]C#N)[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].SC[C@H]([C@@H](CS)O)O.P([O-])([O-])([O-])=O>CCO>[NH2:12][C:10]1[S:11][C:7]2[C:8](=[C:13]([SH:15])[CH:14]=[C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])[CH:6]=2)[N:9]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound was prepared according to General Method 14 using 6-tert-butyl-4-thiocyanato-benzothiazol-2-yl-amine (Example L-6; 2.0 g. 7.6 mmol), dithiothreitol (4.6 g, 30 mmol), phosphate buffer of pH 7 (10 mL), and EtOH (50 mL). The crude product was used further without any purification. MS (APCI): 239 (M+H).
Workup
- customThe crude product was used further without any purification
Sources & evidence
- ORD record
- ord-c023bb652b76466495c6fd9c9529320f
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06852711B2
Reaction notes
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