Reaction equation
CN([CH:4]=[O:5])C.O=P(Cl)(Cl)Cl.[CH2:11]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH3:12]>>[CH2:11]([C:13]1[O:14][C:15]([CH:4]=[O:5])=[CH:16][CH:17]=1)[CH3:12]Participants
4
Conditions
- Temperature
- 0 °C
Procedure
A sample of DMF (9.3 mL, 120 mmol) was cooled to 0° C. and POCl3 (3.37 g, 22 mmol) was added, the mixture was stirred for 1 hour at 0° C., then 2-ethyl furan (1.92 g, 20 mmol) was added. The reaction was quenched by pouring onto ice, and the mixture was stirred for 18 hours. The mixture was extracted with hexane, which was dried over MgSO4 and concentrated to give 1.71 g of the title compound (used without further purification).
Workup
- customThe reaction was quenched
- additionby pouring onto ice
- stirringthe mixture was stirred for 18 hours
- extractionThe mixture was extracted with hexane, which
- dry with materialwas dried over MgSO4
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-8d178fb4c5434ea987c1f70c41398c35
- Source dataset
- uspto-grants-1997_01
- Patent number
- US05597832
Linked notes
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