Triethylamine → Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

HRID 2353486

Reaction equation

HRID 2353486 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][S:18]([CH3:17])(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 933631-Methyl-2-pyrrolidineethanol

Product 1

HCID 44627019Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The 1-methyl-2-pyrrolidineethanol (Aldrich, 0.16 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

Sources & evidence

ORD record
ord-635bb0d0af864afd91106917bbcf7337
Source dataset
uspto-grants-2010_07
Patent number
US07750039B2

Linked notes

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