Hydrochloric Acid → 2-[(2,2,2-Trifluoroacetyl)amino]hexanoic acid

ω-aminocaproic acid (2.59 g, 19.7 mol) was dissolved in 100 mL methanol, and triethylamine (4.2 mL, 29.9 mmol) and ethyl trifluoroacetate (3.5 mL, 29.5 mmol) were added and agitated for a day and night at room temperature. The reaction solution was poured into 1% by weight hydrochloric acid (100 mL), and extracted once with methylene chloride. The methylene chloride layer was washed once with water and once with a saturated aqueous sodium chloride solution, and then dried and concentrated with anhydrous sodium sulfate to obtain 2.78 g of a crude product.

1. extractionextracted once with methylene chloride
2. washThe methylene chloride layer was washed once with water and once with a saturated aqueous sodium chloride solution
3. customdried
4. concentrationconcentrated with anhydrous sodium sulfate

ORD record

ord-c5c898a5e9244e74aa6e3c0d887164ce

Source dataset

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07759473B2